RISK FACTORS AND OUTCOMES FOR LATE PRESENTATION FOR HIV-POSITIVE PERSONS IN EUROPE: RESULTS FROM THE COLLABORATION OF OBSERVATIONAL HIV EPIDEMIOLOGICAL RESEARCH EUROPE STUDY (COHERE).

Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE).

BackgroundFew studies combinaison en tweed have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe.Study objectives were to explore the impact of LP on AIDS and mortality.Methods and findingsLP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagn

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Local inflammation, dissemination and coalescence of lesions are key for the progression towards active tuberculosis: the bubble model

The evolution of a tuberculosis (TB) infection towards active disease is driven by a combination of factors mostly related to the host response.The equilibrium between control of the bacillary load and the pathology generated is crucial as regards preventing the growth and proliferation of TB lesions.In addition, some experimental evidence suggests

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Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.

Glutathione S-transferases (GSTs) are known to abolish or reduce the activities of intracellular enzymes 1.1x1.5 that help detoxify environmental carcinogens, such as those found in tobacco smoke.It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflic

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